In this sitcom, the suddenly risen film star Vince Chase, a 'jeune premier' of humble origins, learns the ropes of the business and the the high-profile world of the wealthy happy few in and around Hollywood, but not alone: he brings form his native New York his atypical 'entourage (hence the title), not glitterati or professionals but a close circle of friends since childhood, and his professional agent finds they often make his job harder as the Queens boys not only sponge on the star but also have his ear, so Vince is much harder to counsel.

Eric gets into a car accident with Anna Faris. After she gave him his number so he could call her for her insurance, he tries to contact her, but finds out she gave him a wrong number. So, he decides to go to her house to talk to her. When they meet, they get along well and Eric actually drives Anna to a meeting for a movie. Meanwhile, Turtle is desperate because the boys ran out of weed, and while getting new drugs, Turtle, accompanied by some girls, gets stopped by the police. Ari has an argument with Mrs. Ari, because she wants to return to her old TV-show "The Young and the Restless" (1973) for a guest-spot, but Ari is totally against it. Especially, after he finds out that his wife is about to kiss another guy.